GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs237743 | 1 | rs6512577 | chr20:47865784 | DDX27 | chr20:47835832-47860612:+ | 0.27 | 4.94 | 1.06E-6 | Height |
| THCA | cis | rs7267979 | 1 | rs6515651 | chr20:25414539 | ENTPD6 | chr20:25176339-25207360:+ | 0.3 | 6.79 | 3.31E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6515651 | chr20:25414539 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.4 | 0.000729 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6515651 | chr20:25414539 | FAM182B | chr20:25744102-25848786:- | -0.25 | -5.23 | 2.5E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6515651 | chr20:25414539 | NINL | chr20:25433338-25566153:- | 0.36 | 7.3 | 1.18E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs6515773 | 1 | rs6515773 | chr20:3174105 | DDRGK1 | chr20:3171018-3185295:- | -0.15 | -3.81 | 0.000159 | Night sleep phenotypes |
| THCA | cis | rs6515773 | 1 | rs6515773 | chr20:3174105 | ITPA | chr20:3190056-3204504:+ | 0.15 | 4.45 | 1.05E-5 | Night sleep phenotypes |
| THCA | cis | rs2832191 | 1 | rs6516891 | chr21:30483070 | C21orf7 | chr21:30449812-30548200:+ | 0.2 | 3.96 | 8.73E-5 | Dental caries |
| THCA | cis | rs2150410 | 1 | rs6517531 | chr21:40637647 | HMGN1 | chr21:40714247-40721270:- | -0.26 | -3.64 | 0.000299 | Temperament (bipolar disorder) |
| THCA | cis | rs651907 | 1 | rs651907 | chr3:101600724 | LOC152225 | chr3:101659703-101716770:+ | 0.16 | 3.39 | 0.000767 | Colorectal cancer |
| THCA | cis | rs2076028 | 1 | rs6519119 | chr22:38989007 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -3.71 | 0.00023 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6519119 | chr22:38989007 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.54 | 0.000447 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6519119 | chr22:38989007 | TOMM22 | chr22:39077954-39080763:+ | -0.16 | -3.55 | 0.000416 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6519120 | chr22:38991393 | JOSD1 | chr22:39081549-39096459:- | 0.15 | 3.88 | 0.000117 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6519120 | chr22:38991393 | LOC646851 | chr22:38974125-39052634:- | -0.13 | -3.59 | 0.000367 | Resting heart rate |